Biotrue Hydration Plus Contact Lens Solution Review – Worth It for Dry Eyes?

Biotrue Hydration Plus Contact Lens Solution with Lens Case, Multi-Purpose Solution for Soft Lenses, Hydrates with Hyaluronan, Cleans, Clears, and Disinfects for All-Day Comfort, 10 Fl Oz (Pack of 2)
Biotrue
- Biotrue Hydration Plus Multi-Purpose Solution keeps MORE MOISTURE on your contacts (for 12 hours compared to original Biotrue Multi-Purpose Solution, based on a laboratory study). Lens Case Included.
- CLEANS & DISINFECTS: Biotrue Hydration Plus contact lens solution provides exceptional cleaning and disinfection. It removes dirt and dissolves protein buildup for clean, clear lenses.
- MORE HYDRATION (vs. original Biotrue Multi-Purpose Solution): It's in the name: Biotrue Hydration Plus. It provides up to 20 hours of moisture (based on a laboratory study). Biotrue Hydration Plus offers all day comfort. It’s enhanced to keep EVEN MORE MOISTURE on your contacts (for 12 hours compared to original Biotrue Multi-Purpose Solution, based on a laboratory study).
- NATURALLY INSPIRED FEATURES: Biotrue Hydration Plus contains naturally inspired ingredients, inspired by the biology of the eye: it’s enhanced with 25% more hyaluronan (a.k.a. HA, a moisturizer found naturally in tears) vs. original Biotrue Multi-Purpose Solution; contains an antioxidant (protects HA against free radicals); as well as potassium (an electrolyte found naturally in tears). Biotrue Hydration Plus also matches the pH of healthy tears to help make contacts comfortable when you put them in.
Quick Verdict
Pros
- Keeps lenses hydrated for up to 20 hours based on laboratory studies
- 25% more hyaluronan than original Biotrue formula
- Matches natural tear pH for comfortable lens insertion
- Includes a quality lens case in every pack
- Effectively removes protein buildup and debris
- Works with all soft lenses including silicone hydrogel
Cons
- Slightly more expensive than standard multi-purpose solutions
- Not suitable for rigid gas permeable (RGP) lenses
- The bottle tip can drip if not handled carefully
- Some users report a mild stinging sensation on sensitive eyes
Quick Verdict
The Biotrue Hydration Plus contact lens solution lives up to its name — I've noticed genuinely less end-of-day dryness compared to the standard multi-purpose solution I used before. The 25% increase in hyaluronan and extended moisture claim of up to 20 hours translates to real comfort, especially if you wear contacts for 10+ hours daily. At roughly $14-16 per 10 fl oz bottle on Amazon, it's competitively priced for what it delivers. I'd rate it 4.4 out of 5 — it earns a recommendation for anyone struggling with afternoon lens dryness.
What Is the Biotrue Hydration Plus Contact Lens Solution?
The Biotrue Hydration Plus is a multi-purpose solution from Bausch + Lomb designed specifically for soft contact lenses, including silicone hydrogel materials. It cleans, disinfects, stores, and rinses your lenses in one bottle — no separate products needed. The "Plus" in the name refers to an enhanced hydration formula compared to the original Biotrue solution, with 25% more hyaluronan (HA), an ingredient naturally found in human tears.

What makes this formula stand out is its biomimetic approach. The solution contains potassium (an electrolyte naturally present in tears) and an antioxidant that protects the hyaluronan from breaking down. It also matches the pH of healthy tears, which sounds like marketing fluff until you feel how smoothly lenses insert after an overnight soak — there's noticeably less of that initial stinging sensation I used to get with other brands.
Key Features
- Keeps lenses hydrated for up to 20 hours based on laboratory testing
- Contains 25% more hyaluronan than the original Biotrue formula
- Matches natural tear pH for comfortable lens insertion every time
- Includes an antioxidant to protect moisture-enhancing ingredients
- Effectively removes protein deposits and debris from lens surfaces
- Provides thorough disinfection against harmful microorganisms
- Works safely with all soft lenses and silicone hydrogel materials
- Lens case bundled in every package
Hands-On Review
I'll be honest — I was skeptical. I've tried so-called "hydration" solutions before that left me reaching for rewetting drops by 2 PM. But after switching to Biotrue Hydration Plus, that afternoon crunch around my corneas faded. By week two, I forgot I was even wearing contacts on several occasions, which hasn't happened for me in years.

The texture of the solution is slightly thicker than standard solutions — not dramatically, but enough that you notice it when you squeeze the bottle. It has that clean, almost medicinal smell you'd expect from an eye product. I use the rub-and-rinse method (rubbing lenses for 20 seconds before the soak, even though some modern solutions don't require it), and the results speak for themselves. After soaking overnight, my lenses feel prepped and ready.
One thing nobody mentions in listings: the bottle design. The cap twists on with a satisfying click, and the dispensing tip gives a controlled stream without spluttering. I dropped the bottle once (don't ask) and it didn't leak, which matters more than you'd think when you're half-asleep doing your nighttime routine. The included lens case snaps shut tightly — no surprise leaks in my bag after commutes.

There's a minor caveat worth noting: on my most sensitive days, usually after staring at screens too long, the first few seconds of lens insertion had a faint sting. Nothing unbearable, but present. After those initial seconds, comfort was solid. If you have particularly finicky eyes, a saline rinse before insertion might help.
Who Should Buy It?
After three weeks of daily use, here's who I think gets the most value from Biotrue Hydration Plus:
- Long-wear contact users: If you regularly wear your lenses for 12+ hours daily, the extended moisture claim isn't just marketing fluff — it genuinely reduces that end-of-day dryness.
- Digital screen workers: Staring at monitors all day already dries out your eyes. This solution helps your contacts fight that battle alongside you.
- Anyone upgrading from basic solution: If you've been using store-brand or entry-level multi-purpose solution and accepting dryness as normal, you'll notice the difference within the first week.
- Silicone hydrogel lens wearers: These lenses breathe better but sometimes attract different deposit patterns — Biotrue handles both cleaning and hydration effectively.
Skip this if you wear rigid gas permeable (RGP) lenses — this formula isn't designed for them. Also skip it if you're looking for the absolute cheapest option and don't mind trading some comfort for savings. And if your eyes are prone to severe allergic reactions to preservatives, talk to your optometrist before trying any new solution.
Alternatives Worth Considering
If Biotrue Hydration Plus doesn't feel like the right fit, here are two solid alternatives:
- Opti-Free PureMoist: Alcon's flagship hydrating solution uses a different wetting agent (Mpolyamine) and also provides excellent long-wear moisture. Many users find it slightly less expensive per ounce. Choose PureMoist if you want to compare hydration performance directly.
- ReNu Fresh Multi-Purpose Solution: Bausch + Lomb's other main line offers reliable cleaning and disinfection at a lower price point. Choose ReNu Fresh if budget matters more than extended moisture claims, though you'll likely sacrifice a few hours of end-of-day comfort.
FAQ
An opened 10 fl oz bottle should be discarded 90 days after first opening, regardless of remaining solution, to ensure proper disinfection performance.
Final Verdict
The Biotrue Hydration Plus contact lens solution does exactly what it promises on the label — it keeps soft contact lenses hydrated longer than the original formula, and the difference is perceptible in daily wear. The naturally inspired ingredient approach (hyaluronan, potassium, antioxidant) isn't just greenwashing; these components genuinely support tear-film-friendly lens care. The inclusion of a lens case and the reliable bottle design are practical touches that add value.
It's not the cheapest option, and if you only wear contacts for 6-8 hours daily, you might not notice enough difference to justify the premium over basic multi-purpose solutions. But for anyone who battles afternoon dryness, works long hours in front of screens, or simply wants their lenses to feel as comfortable at hour 14 as they did at hour 2, this solution is worth every penny. I switched permanently — and that's the most honest endorsement I can give.